I have Delphi XE2 (network named - with update 3) installed on my PC and when I try to register the help files using 'RegHelp2 /i TMSPackdRSXE2.hxx' in the command window I get the following error log generated.
I have created a new VCL application and dropped a standard push button on the form. The first time I press F1 I get the correct help up, then when I close that, and press F1 again I get an error window pop up "No help found for TPersistant".
Clicking on Help -> Delphi Help , I get the Microsoft Document Explorer Window with RAD Studio, Dinkumware, Indy, Rave etc showing on the left hand panel.
I have given the network user (ie me) admin rights to this PC.
TPersistent is a standard VCL class , not a TMS class. So, it would appear your default VCL / IDE help file is damaged. I'd suggest to perform a repair on your IDE Help install.