Where in TMS WEB Core Application is the best place to set global settings for FormatSettings?

WEB TMS WEB Core
1

For example I need global setting for whole app form like this:

FormatSettings.DecimalSeparator := ',';
FormatSettings.ThousandSeparator := #0;

where is the best one place in the web core app?

2

If it is global, it could go in the .DPR source